Dimethylamine → HCID 23144875, Verbindung

HRID 1393056Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393056
Br[CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].[CH3:16][NH:17][CH3:18]>CO>[CH3:16][N:17]([CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7])[CH3:18]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 22509333Methyl 3-(bromomethyl)-2-nitrobenzoate

Produkt 1

HCID 23144875HCID 23144875, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

Methyl 3-bromomethyl-2-nitrobenzoate (1.6 g) was dissolved in methanol (5 mL). Methanol solution (6 mL) of 2M dimethylamine was added thereto and stirred overnight. After removing the solvent, the residue was diluted with 1M hydrochloric acid and washed with ethyl acetate. The water layer was alkalized with sodium hydrate aqueous solution and extracted with ethyl acetate. The usual workup procedure was conducted to obtain methyl 3-dimethylaminomethyl-2-nitrobenzoate.

Aufarbeitung

  1. customAfter removing the solvent
  2. additionthe residue was diluted with 1M hydrochloric acid
  3. washwashed with ethyl acetate
  4. extractionextracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-262f6b9ddb8a4538a5013e4c716fa0b8
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345049B2

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