Sulfuric Acid → HCID 58018321, Verbindung

HRID 1393070

Reaktionsgleichung

Reaktionsgleichung von HRID 1393070
[CH:1]([OH:4])([CH3:3])[CH3:2].S(=O)(=O)(O)O.[N+:10]([C:13]1[CH:34]=[CH:33][C:16]([CH2:17][C@@H:18]([C:30](O)=[O:31])[NH:19][C:20](=[O:29])[C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:15][CH:14]=1)([O-:12])=[O:11]>O1CCCC1>[CH:1]([O:4][C:30](=[O:31])[C@H:18]([CH2:17][C:16]1[CH:15]=[CH:14][C:13]([N+:10]([O-:12])=[O:11])=[CH:34][CH:33]=1)[NH:19][C:20](=[O:29])[C:21]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=1[Cl:28])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 58018322N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine

Produkt 1

HCID 58018321HCID 58018321, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Isopropanol (130 mL), tetrahydrofuran (50 mL) and sulfuric acid (0.44 mL) were added to 4-nitro-N-(2,6-dichlorobenzoyl)-L-phenylalanine (2.95 g, 7.70 mmol) and stirred at 50° C. for 5 days. After removing the solvent under reduced pressure, the obtained solid material was washed with water and dried to obtain 3.28 g of a white solid material.

Aufarbeitung

  1. customAfter removing the solvent under reduced pressure
  2. washthe obtained solid material was washed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7f0384011cc04bccb8a0f3eda6d020dd
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345049B2

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