Trifluoroacetic acid → (4-Ethylamino-phenoxy)-acetic acid ethyl ester

HRID 1393087Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393087
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH2:14][CH3:15])=[CH:9][CH:8]=1)[CH3:2].C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH3:15])=[CH:9][CH:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69220753[4-(Tert-butoxycarbonyl-ethyl-amino)-phenoxy]-acetic acid ethyl ester

Produkt 1

HCID 69220443(4-Ethylamino-phenoxy)-acetic acid ethyl ester

Versuchsvorschrift

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-ethyl-amino)-phenoxy]-acetic acid ethyl ester was deprotected with TFA to give (4-ethylamino-phenoxy)-acetic acid ethyl ester as light brown oil, MS: 224 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-02b31ee3cf3141fa9e93946b2b0e3f07
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345067B2

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