Chloroacetyl chloride → HCID 11600826, Verbindung

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Reaktionsgleichung

[S:1]1[CH2:5][CH:4]([C:6]([NH2:8])=O)[NH:3][CH2:2]1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([N:3]1[C@@H:4]([C:6]#[N:8])[CH2:5][S:1][CH2:2]1)=[O:12]

Komponenten

Edukt 2

HCID 6577Chloroacetyl chloride

HCID 99641014-Thiazolidinecarboxamide

Produkt 1

HCID 11600826HCID 11600826, VerbindungAusbeute 59,1 %

Versuchsvorschrift

In a similar procedure as employed in the Intermediate Example 1, the thiazolidine-4-carboxylic acid amide (102 mg) obtained above was reacted with chloroacetyl chloride (105 mg) and then subjected to dehydration reaction to give the title compound (87 mg, Y.:59%).

Aufarbeitung

customsubjected to dehydration reaction

Quellen und Nachweise

ORD-Eintrag: ord-ceacaa8bf6a54e019a9994089cd3012b
Quelldatensatz: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07345180B2

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