Trifluoroacetic acid → 1-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid

HRID 1393672

Reaktionsgleichung

Reaktionsgleichung von HRID 1393672
C([SiH](CC)CC)C.[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1.FC(F)(F)C(O)=O>ClCCl>[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 70156011-Methyl-1H-indole-5-carboxylic acid

Produkt 1

HCID 230920021-Methyl-2,3-dihydro-1H-indole-5-carboxylic acidAusbeute 65,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Dichloromethane (2 ml) and triethylsilane (1 ml) were added to 1-methyl-1H-indole-5-carboxylic acid (100 mg). The mixture was cooled to 0° C., trifluoroacetic acid (1 ml) was added dropwise thereto, and the mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure, and precipitate was collected by filtration. The precipitate was washed with ether and dried under reduced pressure to give the title compound (66 mg, Y.:65%).

Aufarbeitung

  1. temperaturethe mixture was warmed to room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure, and precipitate
  3. filtrationwas collected by filtration
  4. washThe precipitate was washed with ether
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7ae5d4a85d124e04a59aa672b7dd4228
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345180B2

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