Hydrochloric Acid → 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride

HRID 1394293Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1394293
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) was added 4N-hydrogen chloride in ethyl acetate (100 ml), and the solution was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the concentrate was added diethyl ether. The resulting precipitates were collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the titled compound (30.1 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionto the concentrate was added diethyl ether
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed with diethyl ether
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3b2221855024433592a4772758a93c93
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07348324B2

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