Potassium Iodide → HCID 18538872, Verbindung

Temperatur

80 °C

4-(5-Methyl-1,3,4-thiadiazol-2-ylthio)piperidine trifluoroacetate (59 mg, 0.18 mmol) was dissolved in dry acetonitrile (1.5 mL). To the solution were added 1-acetyl-N-(3-chlorophenyl)-N-(3-chloropropyl)-4-piperidinecarboxamide (50 mg, 0.14 mmol), potassium carbonate (77 mg, 0.56 mmol) and potassium iodide (23 mg, 0.14 mmol), and the mixture was stirred at 80° C. for 5 hours. The mixture was cooled to room temperature, and to the mixture was added saturated sodium chloride solution (3 mL). The mixture was extracted three times with ethyl acetate (2 mL). The extracts were combined and concentrated under reduced pressure. The concentrate; was purified by using HPLC to give the titled compound as a colorless oily substance (32.2 mg, 28%).

1. temperatureThe mixture was cooled to room temperature
2. extractionThe mixture was extracted three times with ethyl acetate (2 mL)
3. concentrationconcentrated under reduced pressure
4. customwas purified

ORD-Eintrag

ord-763433ea3c764cad9991361c4baef56e

Quelldatensatz

uspto-grants-2008_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07348324B2