HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1394986Erstellt: 26. Oktober 2026
1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → Tert-butyl 2-(6-phenylpyrimidin-4-yl)pyrrolidine-1-carboxylate
https://huagongshe.com/reaction/1394986
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| Edukt | 4-Chloro-6-phenylpyrimidine | HCID 593429 | — |
| Reagenz | Cesium carbonate | HCID 10796 | — |
| Katalysator | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Katalysator | Dichloronickel;1,2-dimethoxyethane | HCID 15773433 | — |
| Katalysator | HCID 178441129 | HCID 178441129 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | Tert-butyl 2-(6-phenylpyrimidin-4-yl)pyrrolidine-1-carboxylate | HCID 118426415 | 65% |
Reaktionsschritte
Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes
Herkunft & Nachweise
| DOI | 10.1126/science.1255525 |
|---|
| Quelldatensatz | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
| ORD ID | ord-980f59be0fef4944a93d6d926e7c186a |
|---|
| Quellennotiz | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
