1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester → HCID 86736977, Verbindung

HRID 1395220

Reaktionsgleichung

Reaktionsgleichung von HRID 1395220
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]([NH:12][NH2:13])=[C:6]2[CH:5]=[N:4]1)[CH3:2].N/[C:20](/[CH3:24])=[CH:21]\[C:22]#[N:23]>C(O)CCC>[C:22]([CH2:21][C:20](=[N:13][NH:12][C:11]1[C:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:9][N:8]=[C:7]2[N:3]([CH2:1][CH3:2])[N:4]=[CH:5][C:6]=12)[CH3:24])#[N:23]

Komponenten

4

Edukt 2

HCID 1623571-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 5325263(2Z)-3-Amino-2-butenenitrile

Produkt 1

HCID 86736977HCID 86736977, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

249 g of 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]-pyridine-5-carboxylic acid, ethyl ester (1 mol) and 82 g of 3-aminocrotononitrile (1 mol) are heated together in 1.5 liters of butyl alcohol with stirring for 24 hours. The solvent is removed in vacuo and the residual 4-[2-(2-cyano-1-methylethylidene)hydrazino]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester is recrystallized from alcohol, yield 309 g (80%); m.p. 190°-191°.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. customthe residual 4-[2-(2-cyano-1-methylethylidene)hydrazino]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester is recrystallized from alcohol, yield 309 g (80%)

Quellen und Nachweise

ORD-Eintrag
ord-56ba5e7bb78b41b39353d120daf790b9
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04202899

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