N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide → 2-(2-Dimethylaminoethylamino)-5-methylpyridine

HRID 1395524Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395524
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][N:5]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1)C(=O)C>[OH-].[Na+]>[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][NH:5][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1

Komponenten

3

Edukt 1

HCID 20339535N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide

Produkt 1

HCID 203395792-(2-Dimethylaminoethylamino)-5-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To N-(2-dimethylaminoethyl)-N-(5-methyl-2-pyridyl) acetamide (50.0 g, 0.226 mole) is added 200 ml of 5 N sodium hydroxide. The mixture is stirred rapidly at reflux for 16 hours. The mixture is cooled and the oil is extracted into ether. The ether extract is dried and evaporated under reduced pressure. Distillation of the residue gives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355. Weight obtained is 35 g.

Aufarbeitung

  1. temperatureat reflux for 16 hours
  2. temperatureThe mixture is cooled
  3. extractionthe oil is extracted into ether
  4. extractionThe ether extract
  5. customis dried
  6. customevaporated under reduced pressure
  7. distillationDistillation of the residue
  8. customgives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355
  9. customWeight obtained

Quellen und Nachweise

ORD-Eintrag
ord-1718d04284554ea89fa4944c7c42e1c9
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04203988

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