Ammonia → HCID 86689752, Verbindung

HRID 1396397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1396397
[C:1]([C:5]1[N:10]=[C:9]([NH:11][C:12]2[CH:17]=[C:16]([Cl:18])[N:15]=[N:14][C:13]=2[C:19]([O:21]C)=O)[CH:8]=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].CO.[NH3:25]>>[C:1]([C:5]1[N:10]=[C:9]([NH:11][C:12]2[CH:17]=[C:16]([Cl:18])[N:15]=[N:14][C:13]=2[C:19]([NH2:25])=[O:21])[CH:8]=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 887MethanolHCID 86689751HCID 86689751, Verbindung

Produkt 1

HCID 86689752HCID 86689752, VerbindungAusbeute 92 %

Versuchsvorschrift

Methyl 4-(6-tert-butylpyridin-2-ylamino)-6-chloropyridazine-3-carboxylate (360 mg, 1.12 mmol) was suspended in 7N ammonia in methanol (12 mL, 84.0 mmol) and stirred at room temperature for 16 h. The mixture was concentrated in vacuo to give 4-(6-tert-butylpyridin-2-ylamino)-6-chloropyridazine-3-carboxamide (317 mg, 1.03 mmol, 92%) as a yellow powder. MS (EI/CI) m/z: 306.0 [M+H]. This material was used directly in the next step without further purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1e798ab9a1a140f69d4d2ed88b11b705
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901124B2

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