Ammonia → 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide

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Reaktionsgleichung

[N:1]1([C:6]2[N:11]=[C:10]([NH:12][C:13]3[CH:18]=[C:17]([Cl:19])[N:16]=[N:15][C:14]=3[C:20]([O:22]CC)=O)[CH:9]=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[NH3:25]>CO>[N:1]1([C:6]2[N:11]=[C:10]([NH:12][C:13]3[CH:18]=[C:17]([Cl:19])[N:16]=[N:15][C:14]=3[C:20]([NH2:25])=[O:22])[CH:9]=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1

Komponenten

Reaktionsbedingungen

Temperatur: 25 °C

Versuchsvorschrift

To a solution of ethyl 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxylate (107 mg of ˜83% purity, 258 μmol) in methanol (1 mL) was added ammonia in methanol (2.5 mL, 17.5 mmol) and the mixture warmed at 25° C. for 18 h. The mixture was cooled, filtered, and the collected solid dried in vacuo to give 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide (45 mg, 141 μmol, 55%) as a white solid.

Aufarbeitung

temperatureThe mixture was cooled
filtrationfiltered
customthe collected solid dried in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-9a85db8e21234af7b87a5c3b126edccc
Quelldatensatz: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08901124B2

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