Sulfuric Acid → HCID 58575197, Verbindung

HRID 1396658Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1396658
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1.S(=O)(=O)(O)O.[N+:20]([O-])([O-:22])=[O:21].[K+]>>[F:1][C:2]1[C:11]([N+:20]([O-:22])=[O:21])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 21075354HCID 21075354, Verbindung

Produkt 1

HCID 58575197HCID 58575197, VerbindungAusbeute 87,1 %

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

To a mixture of 1.75 g of methyl 4-fluoro-2-(methoxymethyl)benzoate and 8.7 mL of concentrated sulfuric acid was added 964 mg of potassium nitrate over 5 minutes under cooling at −10° C. After stirring at the same temperature for 4 hours and a half, the reaction mixture was added to 300 mL of ice water, followed by stirring. The solid was collected by filtration, washed with water, and dried under reduced pressure to obtain 1.87 g of methyl 4-fluoro-2-(methoxymethyl)-5-nitrobenzoate.

Aufarbeitung

  1. stirringby stirring
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3a9e0ac0ad8b41f99fa272fcd0846e4b
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901126B2

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