Potassium Carbonate → HCID 46916618, Verbindung

HRID 1396713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1396713
[NH2:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1.[C:18]([O-])([O-])=[O:19].[K+].[K+]>O1CCOCC1.CO>[NH2:1][C:2]1[N:3]=[C:4]([O:19][CH3:18])[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 66759187HCID 66759187, Verbindung

Produkt 1

HCID 46916618HCID 46916618, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 5-amino-2-cyclopropyl-7-(methylsulfonyl)thiazolo[5,4-d]pyrimidine (54 mg, 0.2 mmol) and K2CO3 (69 mg, 0.5 mmol) in dioxane (10 ml) and methanol (5 ml) was stirred at room temperature overnight. The reaction mixture was evaporated in vacuo and purified by flash chromatography on silica, the mobile phase being a mixture of methanol and dichloromethane (in a ratio of 1/60), yielding the pure title compound (40 mg, 90%).

Aufarbeitung

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography on silica
  3. additiona mixture of methanol and dichloromethane (in a ratio of 1/60),

Quellen und Nachweise

ORD-Eintrag
ord-f567f83507e04df293083d718f4dd150
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901132B2

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