Sulfuric Acid → Methyl 4-fluoro-3-methoxybenzoate

HRID 1398221

Reaktionsgleichung

Reaktionsgleichung von HRID 1398221
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12].S(=O)(=O)(O)O.[C:18](=O)([O-])O.[Na+]>CO>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:18])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 5984364-Fluoro-3-methoxybenzoic acid

Produkt 1

HCID 592847Methyl 4-fluoro-3-methoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-fluoro-3-methoxybenzoic acid (2.33 g) and sulfuric acid (0.2 ml) in methanol (20 mL) was heated under reflux for 10 hr, and allowed to cool to room temperature. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, the solvent was evaporated under reduced pressure, and water was added to the residue. The resultant precipitate was collected by filtration to give the title compound (2.31 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 10 hr
  3. customthe solvent was evaporated under reduced pressure, and water
  4. additionwas added to the residue
  5. filtrationThe resultant precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7cc02de77cb94e489f83db78c63b9514
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901309B2

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