Lithium borohydride → HCID 57785932, Verbindung

To a solution of methyl 9-chloro-1-(6-methoxy-2-methylpyridin-3-yl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-6-carboxylate (1.50 g, 3.88 mmol) in tetrahydrofuran (15.0 mL) was added lithium tetrahydroborate (337.8 mg, 15.51 mmol) at 0° C. The reaction mixture was stirred at 50° C. for 6.5 hrs. After cooling, the reaction mixture was quenched with aqueous saturated ammonium chloride at 0° C. The solvent was concentrated and the precipitate was collected by filtration and washed with water to give the title compound as a colorless solid (1.38 g, 3.83 mmol, 99%).

1. temperatureAfter cooling
2. customthe reaction mixture was quenched with aqueous saturated ammonium chloride at 0° C
3. concentrationThe solvent was concentrated
4. filtrationthe precipitate was collected by filtration
5. washwashed with water

ORD-Eintrag

ord-2aedf8ce4bcc45909c333adfbc2f8c50

Quelldatensatz

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08901141B2