Ethyl Acetate → (2S,3S)-2-(4-Chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

HRID 1399531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1399531
[CH3:1][C@H:2]1[C:7](=[O:8])[O:6][CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([Mg]Br)=[CH:14][CH:13]=1.[NH4+].[Cl-].CCOC(C)=O>C1COCC1>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C@:7]2([OH:8])[O:6][CH2:5][C:4]([CH3:10])([CH3:9])[NH:3][C@H:2]2[CH3:1])=[CH:14][CH:13]=1

Komponenten

6

Edukt 4

HCID 8857Ethyl AcetateHCID 25517Ammonium ChlorideHCID 46837646HCID 46837646, VerbindungHCID 178478191HCID 178478191, Verbindung

Produkt 1

HCID 46837780(2S,3S)-2-(4-Chlorophenyl)-3,5,5-trimethylmorpholin-2-olAusbeute 29 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

A solution of 15 (357 mg, 2.50 mmol) in dry THF (2.5 mL, 1M) under an N2 atmosphere was cooled to −78° C. and treated with 4-chlorophenylmagnesium bromide (2 equiv., 5.00 mmol, 5.00 mL, 1M solution in ether). The reaction mixture was stirred at −78° C. for 2 h. A saturated aqueous solution of NH4Cl was added to the reaction vessel, and the mixture was allowed to warm to room temperature. EtOAc was added and the organic layer was separated and the aqueous phase was extracted with EtOAc (trice). The combined organic extracts were washed (water, brine), dried (Na2SO4) and concentrated. The residue was purified by column chromatography on silica gel using CH2Cl2 to CH2Cl2-MeOH (90:10) as the eluent to afford 180 mg (29%) of 4i as a white solid: [α]23D +33° (c 0.4, CHCl3): 1H NMR (CDCl3) δ 7.54 (d, 2H, J=8.5 Hz), 7.32 (d, 2H, J=8.5 Hz), 3.83 (d, 1H, J=11.3 Hz), 3.40 (d, 1H, J=11.3 Hz), 3.18 (q, 1H, J=6.5 Hz), 1.38 (s, 3H), 1.08 (s, 3H), 0.78 (d, 3H, J=6.5 Hz); 13C NMR (CDCl3) δ 128.5, 128.1, 127.6, 127.2, 101.6, 95.9, 69.5, 53.4, 49.7, 27.3, 22.8, 16.4; LCMS (ESI) m/z 256.3 [(M+H)+, M=C13H18ClNO2].

Aufarbeitung

  1. temperatureto warm to room temperature
  2. customthe organic layer was separated
  3. extractionthe aqueous phase was extracted with EtOAc (trice)
  4. washThe combined organic extracts were washed (water, brine)
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated
  7. customThe residue was purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-320f760ddc494641a774dd44b931b548
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906908B2

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