Sodium Hydroxide → 2-(4-(2,3-Dihydrobenzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid
Reaktionsgleichung
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([O:19]C)=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([OH:19])=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
This compound was prepared according to general method D from methyl 2-(4-(2,3-dihydrobenzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.100 g; 0.248 mmol), sodium hydroxide 10N solution (0.248 mL; 2.48 mmol) in methanol (2.5 mL) to afford 0.089 g (91%) of the title compound as a white solid.