Sodium Hydroxide → 2-[4-(2,4-Dimethylphenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acid

HRID 1399702Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1399702
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([O:18]C)=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[N:10]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([OH:18])=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([N:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[N:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66955327Methyl 2-(4-(2,4-dimethylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Produkt 1

HCID 509957302-[4-(2,4-Dimethylphenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acidAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

This compound was prepared according to general method D from 2 methyl 2-(4-(2,4-dimethylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate (0.073 g; 0.185 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h to afford 0.063 g (88%) of the title compound as a white solid.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-463eccf03c934df99f3eea72574f7ce1
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906906B2

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