6-Bromoindole-3-carbaldehyde → 6-Bromo-3-methyl-1H-indole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 6-bromo-1H-indole-3-carbaldehyde (300 mg, 1.34 mmol) in THF (10 mL) was added LiAlH4 (100 mg, 2.63 mmol) at 0° C. The mixture was heated to 70° C. and stirred for 4 h at this temperature. Upon cooling, the reaction solution was quenched with 40% of NaOH and filtered and the filtrate concentrated to give crude product which was used in next step without further purification. LCMS (m/z): 210.1 [M+H]+.

Herkunft & Nachweise