Methyl iodide → 6-Bromo-1,3-dimethyl-1H-indole

HRID 1399863

Reaktionsgleichung

Reaktionsgleichung von HRID 1399863
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].[CH3:14]I>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 534029586-Bromo-3-methyl-1H-indole

Produkt 1

HCID 233835116-Bromo-1,3-dimethyl-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 6-bromo-3-methyl-1H-indole (200 mg, 0.95 mmol) in DMF (8 mL) was added NaH (114 mg, 2.85 mmol, m %/60%). The mixture was stirred at room temperature for 1 h before the addition of MeI (162 mg, 1.14 mmol). The system was stirred at room temperature for 4 h then the mixture was quenched with water and extracted with EtOAc. The organic layer was concentrated to give crude product which was used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.

Aufarbeitung

  1. customthe mixture was quenched with water
  2. extractionextracted with EtOAc
  3. concentrationThe organic layer was concentrated
  4. customto give crude product which
  5. customwas used in next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-46c41d0d9f384c2984f02f3473799030
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906900B2

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