HCID 59233383, Verbindung → HCID 59233384, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:6]=[N:5][C:4]=1[NH:13][CH:14]1[CH2:19][CH2:18][N:17](C(O)=O)[CH2:16][CH2:15]1.C(OC(N1CCC(NC2N=NC(C(F)(F)F)=CC=2OC)CC1)=O)(C)(C)C>CO>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:10])[F:11])[N:6]=[N:5][C:4]=1[NH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 4-(4-Methoxy-6-trifluoromethyl-pyridazin-3-ylamino)-piperidine-1-carboxylic acid tent-butyl ester (D7) (0.73 g, 1.93 mmol) and Amberlyst® 15 ion exchange resin, acidic form (4.1 mmol/g) (2.35 g, 9.65 mmol) in methanol (20 ml) was shaken at room temperature for 18 h. After this period, the mixture was filtered and then a 7M solution of ammonia in methanol was added. The mixture was shaken for 1 h, filtered and the filtrate evaporated in vacuo. The crude product was purified by flash column chromatography (silica gel; 3% ammonia in methanol (7M)/dichloromethane). The desired fractions were collected and evaporated in vacuo. to yield D8 (0.49 g, 92%) as a yellow syrup. C11H15F3N4O requires 276; Found 277 (MH+).