Sodium Hydroxide → 2-(2-Phenyloxazol-4-yl)nicotinic acid

HRID 1400240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1400240
[OH-].[Na+].[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([O:18]CC)=[O:17])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CCO>[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([OH:18])=[O:17])[N:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 67540589Ethyl 2-(2-phenyloxazol-4-yl)nicotinate

Produkt 1

HCID 675401952-(2-Phenyloxazol-4-yl)nicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

An aqueous solution of NaOH (0.27 mL, 2M in water, 0.54 mmol) was added to a solution of ethyl 2-(2-phenyloxazol-4-yl)nicotinate (80 mg, 0.27 mmol) in EtOH (2.7 mL). After stirring overnight at room temperature the solvent was removed in vacuo, the residue was dissolved in water and HCl (2M in water) was added until pH ˜1 was obtained. The solvent was removed in vacuo and the crude product obtained was used without further purification; ESI-MS [M+H+]=267.1.

Aufarbeitung

  1. customwas removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. additionHCl (2M in water) was added until pH ˜1
  4. customwas obtained
  5. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-61af3a1a91dc4ddaba4b262e17fdf8cc
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906941B2

Notizen zur Reaktion

Wird geladen…