Acetoxyacetic acid → N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

HRID 1400921Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1400921
C1(NC(=O)NC2C=CC(OC3C=CN=C4C=C(C5N=CN(CCN6CCN(C(OC(C)(C)C)=O)CC6)C=5)SC=34)=C(F)C=2)CC1.C1(NC(NC2C=CC(OC3C=CN=C4C=C(C5C=CC(CN6CCNCC6)=CN=5)SC=34)=C(F)C=2)=O)CC1.C(OCC(O)=O)(=O)C.C([O:93][CH2:94][C:95]([N:97]([CH2:102][C:103]1[CH:104]=[N:105][C:106]([C:109]2[S:117][C:116]3[C:111](=[N:112][CH:113]=[CH:114][C:115]=3[O:118][C:119]3[CH:120]=[N:121][C:122]([NH:125][C:126]([NH:128][CH:129]4[CH2:131][CH2:130]4)=[O:127])=[CH:123][CH:124]=3)[CH:110]=2)=[CH:107][CH:108]=1)[CH2:98][CH2:99][O:100][CH3:101])=[O:96])(=O)C>>[CH:129]1([NH:128][C:126](=[O:127])[NH:125][C:122]2[N:121]=[CH:120][C:119]([O:118][C:115]3[CH:114]=[CH:113][N:112]=[C:111]4[CH:110]=[C:109]([C:106]5[N:105]=[CH:104][C:103]([CH2:102][N:97]([CH2:98][CH2:99][O:100][CH3:101])[C:95](=[O:96])[CH2:94][OH:93])=[CH:108][CH:107]=5)[S:117][C:116]=34)=[CH:124][CH:123]=2)[CH2:130][CH2:131]1

Komponenten

5

Edukt 4

HCID 83766Acetoxyacetic acidHCID 67440535tert-butyl 4-(2-(4-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1H-imidazol-1-yl)ethyl)piperazine-1-carboxylateHCID 674421792-(((6-(7-(6-(3-Cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)(2-methoxyethyl)amino)-2-oxoethyl acetateHCID 674423881-Cyclopropyl-3-(3-fluoro-4-(2-(5-(piperazin-1-ylmethyl)pyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea2×

Produkt 1

HCID 67442923N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

Versuchsvorschrift

Compounds 309 (example 167) and 310 (example 168) were prepared by reacting compounds 307 (scheme 68) and compound 49 (scheme 15) with acetoxyacetic acid, similarly to compound 30 (scheme 13). Compound 311 (example 169) was synthesized by following the procedures described above for the synthesis of compound 49 (scheme 15). Compounds 312 (example 170) and 313 (example 171) were obtained similarly to compound 31 (scheme 13). Compound 314 (example 172) was synthesized by following the procedures described above for the synthesis of compound 75 (scheme 20).

Aufarbeitung

  1. customCompounds 309 (example 167) and 310 (example 168) were prepared
  2. customCompound 311 (example 169) was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-d839a54d74cb4d2889266850b5236450
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906852B2

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