Hydrochloric Acid → HCID 67324366, Verbindung

HRID 1401784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1401784
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.C(OC([N:34]1[CH2:38][CH2:37][C@H:36]([OH:39])[C@H:35]1[C:40](O)=[O:41])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH:25][C:40]([C@@H:35]5[C@@H:36]([OH:39])[CH2:37][CH2:38][NH:34]5)=[O:41])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14037017(2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acidHCID 53312200HCID 53312200, Verbindung

Produkt 1

HCID 67324366HCID 67324366, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The preparation was carried out analogously starting from 244 mg (0.50 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine and 116 mg (0.50 mmol) of (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. The protecting group was cleaved off analogously using HCl in dioxane. The product was purified by means of flash chromatography on silica gel.

Aufarbeitung

  1. customThe product was purified by means of flash chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-ddc62276da474bd4bbad61cf84768d28
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907098B2

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