Aluminium lithium hydride → HCID 67323188, Verbindung

HRID 1401786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1401786
[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C@@H:9]1[C:13]([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[S:22][CH:23]=[C:24]([C:26]3[CH:35]=[CH:34][C:33]4[C:32]([CH3:37])([CH3:36])[CH2:31][CH2:30][C:29]([CH3:39])([CH3:38])[C:28]=4[CH:27]=3)[N:25]=2)[CH2:17][CH2:16]1)=O>C1COCC1>[CH3:36][C:32]1([CH3:37])[CH2:31][CH2:30][C:29]([CH3:38])([CH3:39])[C:28]2[CH:27]=[C:26]([C:24]3[N:25]=[C:21]([CH:18]4[CH2:17][CH2:16][N:15]([CH2:13][C@@H:9]5[C@@H:8]([OH:7])[CH2:12][CH2:11][NH:10]5)[CH2:20][CH2:19]4)[S:22][CH:23]=3)[CH:35]=[CH:34][C:33]1=2

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 67323751HCID 67323751, Verbindung

Produkt 1

HCID 67323188HCID 67323188, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The preparation was carried out as already described using a 2N lithium aluminium hydride solution in THF starting from 30 mg (0.06 mmol) of ((2S,3S)-3-hydroxypyrrolidin-2-yl)-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-1-yl}methanone. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-3beb4fc1e3434a808a72517ef4ec76b1
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907098B2

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