2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ol

HRID 1401830

Reaktionsgleichung

Reaktionsgleichung von HRID 1401830
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)=O.[OH:19][CH:20]1[CH2:25][CH2:24][N:23]([C:26](=[S:28])[NH2:27])[CH2:22][CH2:21]1>>[CH3:15][C:11]1([CH3:16])[CH2:10][CH2:9][C:8]([CH3:17])([CH3:18])[C:7]2[CH:6]=[C:5]([C:3]3[N:27]=[C:26]([N:23]4[CH2:24][CH2:25][CH:20]([OH:19])[CH2:21][CH2:22]4)[S:28][CH:2]=3)[CH:14]=[CH:13][C:12]1=2

Komponenten

3

Edukt 2

HCID 28013372-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-oneHCID 167909664-Hydroxypiperidine-1-carbothioamide

Produkt 1

HCID 533116261-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ol

Versuchsvorschrift

The preparation was carried out as already described starting from 397 mg (0.94 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 100 mg (0.62 mmol) of 4-hydroxypiperidine-1-carbothioic acid amide from step a. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-cb75d02964c044f18c3f1ad37356523b
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907098B2

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