HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 14025Erstellt: 23. Oktober 2026
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 44426035, Verbindung
https://huagongshe.com/de/reaction/14025
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid | HCID 22394891 | — |
| Edukt | (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol Trifluoroacetate | HCID 69869154 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | HCID 44426035 | HCID 44426035 | — |
Reaktionsschritte
A mixture of 3-(cyanomethyl)-5-[(dipropylamino)carbonyl]benzoic acid (IX, 0.13 g), (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII, 0.14 g), HATU (0.17 g), and dichloromethane (10 mL) is stirred at 40 degrees C. overnight. After cooling, the mixture is washed with water and the organic phase is separated and dried over magnesium sulfate and taken to dryness under reduced pressure. Chromatography (silica gel) gives the title compound, M+H=571.2
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07727997B2 |
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| Quelldatensatz | uspto-grants-2010_06 |
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| ORD ID | ord-20201984300a44be9a2d0db57120a64f |
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| Quellennotiz | uspto-grants-2010_06 |
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