Sodium Hydroxide → (6-Methylpyridin-3-yl)acetic acid
Reaktionsgleichung
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 65 °C
Versuchsvorschrift
To a stirred solution of methyl (6-methylpyridin-3-yl)acetate (60 mg, 0.36 mmol) in methanol (5 ml) was added NaOH (1.0 ml of a 2M aqueous solution, 2.0 mmol) and the resulting solution was heated at 65° C. for 2 hours. The solvent was then removed at reduced pressure and the resulting residue was dissolved in methanolic HCl (5 ml) and then reconcentrated to yield the title product (54 mg, quant. yield) that was used without further purification.
Aufarbeitung
- customThe solvent was then removed at reduced pressure
- dissolutionthe resulting residue was dissolved in methanolic HCl (5 ml)
Quellen und Nachweise
- ORD-Eintrag
- ord-c3ba509f4e4840ceab22ea9d201ac51e
- Quelldatensatz
- uspto-grants-2014_12
- Patentnummer
- US08912176B2
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