(4-Bromophenyl)boronic acid → HCID 90406588, Verbindung

HRID 1404166

Reaktionsgleichung

Reaktionsgleichung von HRID 1404166
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[Br:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1.[CH3:24][C:25]1[C:30]([CH3:31])=[C:29]([OH:32])[CH:28]=[CH:27][C:26]=1[CH2:33][CH2:34]C(OCC)=O>>[Br:14][C:15]1[CH:20]=[CH:19][C:18]([N:5]2[CH:6]=[CH:7][C:3]([C:2]([F:13])([F:12])[F:1])=[C:4]2[CH2:8][O:10][C:11]2[CH:34]=[CH:33][C:26]([CH2:27][CH2:28][CH2:29][OH:32])=[C:25]([CH3:24])[C:30]=2[CH3:31])=[CH:17][CH:16]=1

Komponenten

4

Edukt 3

HCID 79599(4-Bromophenyl)boronic acidHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90405535methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate

Produkt 1

HCID 90406588HCID 90406588, Verbindung

Versuchsvorschrift

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.

Quellen und Nachweise

ORD-Eintrag
ord-c8dd5bd5855748349a751e0f021ffaa0
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08912227B1

Verknüpfte Notizen

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