Phenylboronic Acid → 3-(2,3-Dimethyl-4-{[1-phenyl-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol

HRID 1404167

Reaktionsgleichung

Reaktionsgleichung von HRID 1404167
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[C:14]1(B(O)O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:23][C:24]1[C:29]([CH3:30])=[C:28]([OH:31])[CH:27]=[CH:26][C:25]=1[CH2:32][CH2:33]C(OCC)=O>>[CH3:23][C:24]1[C:29]([CH3:30])=[C:11]([O:10][CH2:8][C:4]2[N:5]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:6]=[CH:7][C:3]=2[C:2]([F:13])([F:12])[F:1])[CH:33]=[CH:32][C:25]=1[CH2:26][CH2:27][CH2:28][OH:31]

Komponenten

4

Edukt 3

HCID 66827Phenylboronic AcidHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90405535methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate

Produkt 1

HCID 904064623-(2,3-Dimethyl-4-{[1-phenyl-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol

Versuchsvorschrift

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and phenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.

Quellen und Nachweise

ORD-Eintrag
ord-c3769d36aa444669a08c50cd86a55d3a
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08912227B1

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