Hydrochloric Acid → 2-(Benzo[d]thiazol-2-yloxy)acetic acid

HRID 1404942Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1404942
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([OH:14])=[O:13]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59467898HCID 59467898, Verbindung

Produkt 1

HCID 2435072-(Benzo[d]thiazol-2-yloxy)acetic acidAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 60 (1.32 g, 5.6 mmol) in MeOH was added NaOH (3M, 75 mL, 0.22 mol) dropwise. The mixture was stirred at room temperature over night. It was then cooled in an ice-water bath and acidified to pH<2 with HCl (2N). The mixture was then extracted with CHCl3 (3×). The combined organic layers were dried over Na2SO4 and concentrated in vacuum to yield 61 as a white solid (1.0 g, 86%).

Aufarbeitung

  1. temperatureIt was then cooled in an ice-water bath
  2. extractionThe mixture was then extracted with CHCl3 (3×)
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-506823504202427ba8fc1d607fb1f1c8
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916550B2

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