2,3-Dihydro-1,4-benzodioxin-5-ylboronic acid → HCID 66576432, Verbindung

HRID 1405186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1405186
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[O:20]1[C:25]2[CH:26]=[CH:27][CH:28]=[C:29](B(O)O)[C:24]=2[O:23][CH2:22][CH2:21]1>>[O:20]1[C:25]2[CH:26]=[CH:27][CH:28]=[C:29]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=4)[N:3]=3)[C:24]=2[O:23][CH2:22][CH2:21]1

Komponenten

3

Edukt 2

HCID 46831952,3-Dihydro-1,4-benzodioxin-5-ylboronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Produkt 1

HCID 66576432HCID 66576432, Verbindung

Versuchsvorschrift

Example 18 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and 2,3-dihydro-1,4-benzodioxin-5-ylboronic acid (Combi-Blocks Inc.). The batch was purified by preparative HPLC.

Aufarbeitung

  1. customExample 18 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-1244fdc8e4ff43e1ab58911cced7b124
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916557B2

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