{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acid → HCID 66576517, Verbindung

HRID 1405189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1405189
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1B(O)O>>[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 16218053{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Produkt 1

HCID 66576517HCID 66576517, Verbindung

Versuchsvorschrift

Example 26 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and {2-[(3-fluorobenzyl)oxy]phenyl}boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.

Aufarbeitung

  1. customExample 26 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-d206671fc88e4abaa1b56fabeae7a13b
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916557B2

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