(2-((2-Chlorobenzyl)oxy)phenyl)boronic acid → HCID 66576518, Verbindung

HRID 1405190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1405190
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[Cl:20][C:21]1[CH:37]=[CH:36][CH:35]=[CH:34][C:22]=1[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1B(O)O>>[Cl:20][C:21]1[CH:37]=[CH:36][CH:35]=[CH:34][C:22]=1[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 16217764(2-((2-Chlorobenzyl)oxy)phenyl)boronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Produkt 1

HCID 66576518HCID 66576518, Verbindung

Versuchsvorschrift

Example 27 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and {2-[(2-chlorobenzyl)oxy]phenyl}boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.

Aufarbeitung

  1. customExample 27 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-c57b3a102b6b45ebab7894b383ef1f62
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916557B2

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