1-Cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione → HCID 71607922, Verbindung
Reaktionsgleichung
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[NH:6][C:5]2=[O:19])[CH2:3][CH2:2]1.CS(O[CH2:25][CH2:26][CH2:27][C@@H:28]1[O:32][C:31](=[O:33])[N:30]([C:34]2[CH:35]=[CH:36][C:37]3[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=3[CH:44]=2)[CH2:29]1)(=O)=O>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11]([F:16])[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[N:6]([CH2:25][CH2:26][CH2:27][C@@H:28]3[O:32][C:31](=[O:33])[N:30]([C:34]4[CH:35]=[CH:36][C:37]5[S:42][CH2:41][C:40](=[O:43])[NH:39][C:38]=5[CH:44]=4)[CH2:29]3)[C:5]2=[O:19])[CH2:2][CH2:3]1Komponenten
3
Versuchsvorschrift
Starting from 1-cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione (described in Org. Process Res. Dev. (2007), 11(3), 441-449) and 6-[(5S)-5-[3-[(methylsulfonyl)oxy]propyl]-2-oxo-3-oxazolidinyl]-2H-1,4-benzothiazin-3(4H)-one (prepared according to WO 2010/041194) and using Procedure E, the title compound was obtained as a colourless solid (140 mg; 65% yield).
Quellen und Nachweise
- ORD-Eintrag
- ord-a3ca26a20ba04dbfbbb703d8c3850e36