4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile → 4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamine

HRID 1406330Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1406330
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1>N.[Ni]>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([CH2:11][NH2:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1

Komponenten

4

Edukt 1

HCID 667894214-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile

Produkt 1

HCID 584879074-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittel

Versuchsvorschrift

1.0 g (3.76 mmol) of 4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile were hydrogenated in 30 mL methanolic ammonia solution with the addition of Raney nickel at 50° C. under a hydrogen pressure of 50 psi. Then the catalyst was filtered off and the filtrate was evaporated to dryness. The crude product thus obtained was reacted further without any further purification.

Aufarbeitung

  1. filtrationThen the catalyst was filtered off
  2. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-e937f86b4fdf4fd49a4a5821587aecaa
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916589B2

Notizen zur Reaktion

Wird geladen…