Ammonia → 1-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine

HRID 1406333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1406333
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[N:15]O)[CH3:14])=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.N.[H][H]>CO.[Ni]>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:11][CH:12]=2)=[C:4]([F:19])[CH:3]=1

Komponenten

6

Edukt 3

HCID 222AmmoniaHCID 866588121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oximeHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 584879121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamineAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2.60 g (9.3 mmol) of 1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oxime were dissolved in 20 mL methanol, then combined with 30 mL 7N methanolic ammonia solution and after the addition of 0.2 g Raney nickel hydrogenated at ambient temperature and 50 psi hydrogen pressure. Then the catalyst was filtered off and the filtrate was evaporated down. The crude product thus obtained was reacted further without any further purification.

Aufarbeitung

  1. customhydrogenated at ambient temperature
  2. filtrationThen the catalyst was filtered off
  3. customthe filtrate was evaporated down

Quellen und Nachweise

ORD-Eintrag
ord-3d8902e9953a4ddfa68ff2712a45a7f9
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916589B2

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