Ethanol → Ethyl 4-amino-2-fluoro-5-nitrobenzoate

Reaktionsgleichung

[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:14])[CH:3]=1.[CH2:15]([OH:17])[CH3:16]>>[CH2:15]([O:17][C:6](=[O:7])[C:5]1[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]([NH2:1])=[CH:3][C:4]=1[F:14])[CH3:16]

Komponenten

Edukt 2

HCID 702Ethanol

HCID 866603804-Amino-5-nitro-2-fluoro-benzoyl chloride

Produkt 1

HCID 59529828Ethyl 4-amino-2-fluoro-5-nitrobenzoateAusbeute 89 %

Versuchsvorschrift

A solution of the product obtained at 149e (1.4 g, 6.4 mmol) in 50 mL ethanol was heated to reflux for 2 h. The mixture was filtered and the filtrate concentrated i.vac. The residue is reacted without any further purification. Yield: 89%.

Aufarbeitung

temperaturewas heated
temperatureto reflux for 2 h
filtrationThe mixture was filtered
concentrationthe filtrate concentrated i.vac
customThe residue is reacted without any further purification

Quellen und Nachweise

ORD-Eintrag: ord-bb09c702cf3849beb02397cf6bbc8c08
Quelldatensatz: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08916599B2

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