HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hexane → methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hexane | HCID 8058 | — |
| Edukt | Trimethylsilyldiazomethane | HCID 167693 | — |
| Edukt | O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine | HCID 15058464 | — |
| Lösungsmittel | Benzene methanol | HCID 21927730 | — |
| Produkt | methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate | HCID 54564501 | — |
Reaktionsschritte
To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07727997B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-92306b3288f94584930245ab3ab8e0d5 |
| Quellennotiz | uspto-grants-2010_06 |