Thionyl Chloride → HCID 58897002, Verbindung

HRID 1409109Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1409109
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[CH:17][C:18]([C:19]4[CH:20]=[C:21]([CH2:25]O)[CH:22]=[CH:23][CH:24]=4)=[C:13]3[CH:12]=[CH:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.S(Cl)([Cl:30])=O>ClCCl>[Cl:30][CH2:25][C:21]1[CH:20]=[C:19]([C:18]2[CH:17]=[CH:16][N:15]=[C:14]3[N:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([CH3:27])=[CH:2][CH:3]=4)(=[O:9])=[O:8])[CH:11]=[CH:12][C:13]=23)[CH:24]=[CH:23][CH:22]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 58896939HCID 58896939, Verbindung

Produkt 1

HCID 58897002HCID 58897002, VerbindungAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (G) (0.25 g, 0.66 mmol) in dichloromethane (5 mL) was added thionyl chloride (0.5 mL, 6.9 mmol) at RT. The solution was allowed to stir until complete as judged by HPLC (1 hour). The solvent was removed under reduced pressure to afford 0.26 g of (H) (99% yield) as a white solid. FIA MS expected for C21H17ClN2O2S: m/e 396.07, found: 396.8 ES+. The material was used without further purification.

Aufarbeitung

  1. customas judged by HPLC (1 hour)
  2. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5efb3547f1094afc9081e0d58f457ea9
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921376B2

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