Ammonia → HCID 136268158, Verbindung
Reaktionsgleichung
[OH:1][C:2]1[C:7](=[O:8])[NH:6][C:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18](C)[CH:17]=2)=[N:4][C:3]=1[C:23](OC)=[O:24].[NH3:27].[CH3:28]O>>[OH:1][C:2]1[C:7](=[O:8])[NH:6][C:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:28])[CH:17]=2)=[N:4][C:3]=1[C:23]([NH2:27])=[O:24]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A mixture containing methyl 5-hydroxy-2-((3′-methylbiphenyl-2-yl)methyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate (55 mg, 157 μmol) and ammonia (7M in MeOH) (4 ml, 28.0 mmol) in MeOH (2 ml) was heated at 100° C. overnight. The cooled reaction mixture was concentrated in vacuo and then triturated from methanol to give the title product as an off-white solid (0.025 g; 47%). LCMS: m/z=336 (MH+).