HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,5-Dichloropyrimidine → (3S,4R)-1-(5-chloropyrimidin-2-yl)-N-cyclopropyl-3-fluoropiperidin-4-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,5-Dichloropyrimidine | HCID 590641 | — |
| Edukt | tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate | HCID 68290240 | — |
| Produkt | (3S,4R)-1-(5-chloropyrimidin-2-yl)-N-cyclopropyl-3-fluoropiperidin-4-amine | HCID 71093748 | — |
Reaktionsschritte
The title compound is prepared from tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate and 2,5-dichloropyrimidine following a procedure analogous to that described for Intermediate 87. LC (method 20): tR=1.86 min; Mass spectrum (APCI): m/z=271 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08921398B2 |
| Quelldatensatz | uspto-grants-2014_12 |
| ORD ID | ord-1c301df210d54958949cb8a1ab2289d7 |
| Quellennotiz | uspto-grants-2014_12 |