6-(1H-imidazol-1-yl)pyridazine-3-carboxylic acid → 6-Imidazol-1-yl-pyridazine-3-carboxylic acid cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amide
Reaktionsgleichung
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[N:19]1([C:24]2[N:29]=[N:28][C:27]([C:30](O)=[O:31])=[CH:26][CH:25]=2)[CH:23]=[CH:22][N:21]=[CH:20]1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:12]=[CH:13][C:14]([CH2:17][CH3:18])=[CH:15][N:16]=3)[CH2:7][CH2:6]2)[C:30]([C:27]2[N:28]=[N:29][C:24]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)=[CH:25][CH:26]=2)=[O:31])[CH2:2][CH2:3]1Komponenten
3
Versuchsvorschrift
The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 6-imidazol-1-yl-pyridazine-3-carboxylic acid following a procedure analogous to that described in Example 1. LC (method 13): tR=2.44 min; Mass spectrum (ESI+): m/z=419 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-5b81ece698344ecca9cd6d206d9f4d90