Ammonia → 5-(Aminomethyl)-2-chloroaniline

HRID 1410202Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1410202
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[C:5]#[N:6].N>CO.[Ni]>[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6]

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 1044643-Amino-4-chlorobenzonitrile

Produkt 1

HCID 134650975-(Aminomethyl)-2-chloroaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 3-Amino-4-chloro-benzonitrile (1.32 g, 8.33 mmol), Ra-Nickel (0.25 g) and 80 ml NH3 in MeOH was stirred for 4 h at rt under H2-atmosphere (3 bar). The mixture was filtered and concentrated and the sub-title compound was used without further purification.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customthe sub-title compound was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5a3bb122349746c6a1bc91a430c324ba
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921405B2

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