Trifluoroacetic acid → HCID 68510963, Verbindung
Reaktionsgleichung
C(O)(C(F)(F)F)=O.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:18]2[CH:44]=[CH:43][C:21]3[N:22]([CH3:42])[C:23]([NH:25][C:26]4[CH:27]=[C:28]([CH:38]=[CH:39][C:40]=4[Cl:41])[CH2:29][NH:30]C(=O)OC(C)(C)C)=[N:24][C:20]=3[CH:19]=2)=[O:17])=[CH:11][CH:10]=1>C(Cl)Cl>[NH2:30][CH2:29][C:28]1[CH:38]=[CH:39][C:40]([Cl:41])=[C:26]([NH:25][C:23]2[N:22]([CH3:42])[C:21]3[CH:43]=[CH:44][C:18]([C:16]([NH:15][C:12]4[CH:11]=[CH:10][C:9]([Br:8])=[CH:14][CH:13]=4)=[O:17])=[CH:19][C:20]=3[N:24]=2)[CH:27]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
TFA (1.5 mL) was added to tert-butyl 3-[5-(4-bromophenylcarbamoyl)-1-methyl-2-benzimidazolylamino]-4-chlorobenzylcarbamate (960 mg. 1.7 mmol prepared in analogy to the experimental procedures described above) in DCM (20 mL) at rt. After 16 h at rt TFA (2 mL) was added and the mixture was stirred at rt for 16 h, diluted with DCM and washed with NaHCO3 (aq, sat) and brine, dried and concentrated to give the sub-title compound which was used in the next step without further purification. Yield: 706 mg (90%)