Methyl 3-amino-4-(methylamino)benzoate → Methyl 2-{5-[(tert-Butoxycarbonylamino)methyl]-2-chlorophenylamino}-1-methylbenzimidazole-5-carboxylate
Reaktionsgleichung
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:4][C:3]=1[N:17]=[C:18]=S.[NH2:20][C:21]1[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=1[NH:31][CH3:32])[C:24]([O:26][CH3:27])=[O:25]>>[C:10]([O:9][C:8]([NH:7][CH2:6][C:5]1[CH:15]=[CH:16][C:2]([Cl:1])=[C:3]([NH:17][C:18]2[N:31]([CH3:32])[C:30]3[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][C:21]=3[N:20]=2)[CH:4]=1)=[O:14])([CH3:13])([CH3:12])[CH3:11]Komponenten
3
Versuchsvorschrift
The sub-title compound was prepared from tert-butyl 4-chloro-3-isothiocyanatobenzylcarbamate (see Example 2d) and methyl 3-amino-4-methylaminobenzoate according to Example 3, step (g).
Quellen und Nachweise
- ORD-Eintrag
- ord-fd0011f550eb472e8bb0243ebbb91d87
- Quelldatensatz
- uspto-grants-2014_12