5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide → (R)-5-chloro-N1-(5-chlorothiazol-2-yl)-N1'-methylspiro[indoline-3,3'-pyrrolidine]-1,1'-dicarboxamide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]2[C@:10]3([CH2:14][CH2:13][NH:12][CH2:11]3)[CH2:9][N:8]([C:15]([NH:17][C:18]3[S:19][C:20]([Cl:23])=[CH:21][N:22]=3)=[O:16])[C:5]2=[CH:6][CH:7]=1.ClC1C=C2C3(CCNC3)C[N:31]([C:38](NC3SC(Cl)=CN=3)=[O:39])[C:28]2=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C@@:10]3([CH2:14][CH2:13][N:12]([C:38]([NH:31][CH3:28])=[O:39])[CH2:11]3)[CH2:9][N:8]([C:15]([NH:17][C:18]3[S:19][C:20]([Cl:23])=[CH:21][N:22]=3)=[O:16])[C:5]2=[CH:6][CH:7]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 373, with the exception that the (S)-5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide obtained as an intermediate of Example 52 was used instead of 5-chloro-N-(5-chlorothiazol-2-yl)spiro[indoline-3,3′-pyrrolidine]-1-carboxamide.