1-(4-Bromo-3-methylphenyl)ethanone → 2-Bromo-1-(4-bromo-3-methylphenyl)ethan-1-one

HRID 1411343

Reaktionsgleichung

Reaktionsgleichung von HRID 1411343
[Br-:1].[Br-].[Br-].C[N+](C)(C)C1C=CC=CC=1.C[N+](C1C=CC=CC=1)(C)C.C[N+](C1C=CC=CC=1)(C)C.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([C:41](=[O:43])[CH3:42])=[CH:37][C:36]=1[CH3:44]>C1COCC1>[Br:1][CH2:42][C:41]([C:38]1[CH:39]=[CH:40][C:35]([Br:34])=[C:36]([CH3:44])[CH:37]=1)=[O:43]

Komponenten

4

Edukt 2

HCID 3471241-(4-Bromo-3-methylphenyl)ethanoneHCID 17977687Phenyltrimethylammonium bromide dibromide

Produkt 1

HCID 591663462-Bromo-1-(4-bromo-3-methylphenyl)ethan-1-oneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Trimethyl phenylammonium tribromide (13 g, 0.036 mol) was added to a solution of 1-(4-bromo-3-methyl-phenyl)-ethanone (6.3 g, 0.030 mol) in THF (30 mL) and the reaction mixture was stirred at RT for 12 h, filtered, and concentrated to provide the title intermediate (8.6 g, 100% yield). 1H NMR (CDCl3, 400 MHz) δ (ppm): 7.82 (m, 1H), 7.66 (m, 2H), 4.38 (s, 2H), 2.56 (s, 3H)

Aufarbeitung

  1. filtrationfiltered
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7319e3f7c10a44148aa65823923fbbd4
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921372B2

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