Thionyl Chloride → 5-chloro-4-(chloromethyl)-3-methyl-1-phenyl-1H-pyrazole

HRID 1413101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413101
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH2:14]O.S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH2:14][Cl:18]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 940312(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanol

Produkt 1

HCID 49627755-chloro-4-(chloromethyl)-3-methyl-1-phenyl-1H-pyrazole

Versuchsvorschrift

6.1 g of 5-chloro-4-hydroxymethyl-3-methyl-1-phenylpyrazole are added portionwise to 50 ml of thionylchloride. The mixture is refluxed for 2 hours, the excess thionylchloride distilled off, the oily product treated with water and then extracted with ether. The dried ethereal extract is evaporated in vacuo yielding 6.1 g of oily 5-chloro-4-chloromethyl-3-methyl-1-phenylpyrazole which, without further purification, is used in the next reaction step.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 2 hours
  2. distillationthe excess thionylchloride distilled off
  3. additionthe oily product treated with water
  4. extractionextracted with ether
  5. extractionThe dried ethereal extract
  6. customis evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-388b9d62d787454981ddacf6ae52855f
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04248881

Notizen zur Reaktion

Wird geladen…